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Extra Valeric Acid Can Be Used To Treat Rheumatoid Arthritis

Shandong Minji Chemical Co.,Ltd | Updated: Oct 27, 2017

Pentate is a raw material for fine chemical products such as pesticides, pharmaceuticals, spices, plasticizers, paints, specialty chemicals and polymeric additives, Pivalic Acid and is often synthesized industrially with Koch to synthesize pivalic acid.

Tert-valeric acid, also known as trimethyl acetic acid. Needle crystal. The relative density of 0.905 (50 ℃). Melting point 35.3 ~ 35.5 ℃. The boiling point of 163.7 ~ 163.8 ℃.

Pivalic acid, alias pivalic acid, trimethylacetic acid, 2,2-dimethylpropionic acid as white crystals, m.p. 35.SC, boiling point 163.7 ° C, relative density 0.905 (50 ° C), refractive index 2.393 (36.5 C). Soluble in water, soluble in alcohol ether, with corrosive. Fent valeric acid is an important chemical raw material and chemical reagents, because it is connected to the tertiary carbon atoms, Pivalic Acid the formation of a stable molecular structure, it shows a special physical and chemical properties, as organic intermediates, Pivalic Acid in fine chemical synthesis Has a wide range of applications, is one of the most widely used alkyl succinic acid.

The initiator PV prepared with pivaloyl chloride and then reacted with t-butyl peroxide is an efficient initiator for high pressure polyethylene, also called BPP initiator. The thermal stability of the resin produced by BPP is better than that of the resin using nitrile initiator. Pivalic Acid It also has a good effect on the high pressure copolymerization of E · vA. The special valeric acid is the intermediate of some drug synthesis, Pivalic Acid and the pivaloyl chloride can be used for the synthesis of ampicillin; Phosphorus-substituted pivalate has the effect of preventing pancreatic enzyme (elastase) activity, can treat emphysema, atherosclerosis and rheumatoid arthritis; special valeric acid is also used for plasticizers, paints and paint dry Agents, lubricants, glycidols, dispersants, perfumes and pesticide synthesis and so on.

The In recent years, a variety of new pharmaceuticals, pesticides, Pivalic Acid coatings and other intermediates are special valeric acid as the starting material, these intermediates show a very bright future, domestic and international market consensus, many intermediates have become hot development products, Downstream market huge development space to stimulate and promote the production and development of special valeric acid.

Aspartic acid because of its structure of the particularity, in the synthesis of fine chemical products has a wide range of applications. Widely used in pesticides, pharmaceuticals, initiators, Pivalic Acid coatings and many other areas.

Pesticide applications

A variety of new pesticide fungicides, plant growth regulators and insecticides, such as triazole alcohols, benzyl chlorotriazole alcohols, triazolones (paclitaxel) ), Paclobutrazol, dibenzoylenol, idiopheneazole, ketazolone, tebuconazole, arachidazole, squandazole, squalone and the like. Pivalic Acid These products have the characteristics of high efficiency, low toxicity, internal absorption, broad spectrum, low dosage and long residual effect. They have good control effect on the pests and diseases such as rice, wheat, soybean, fruit trees and vegetables.

Medical applications

Pivaloyl chloride is the production of furosemide, double effect of the adrenal gland table of raw materials, can also be used to produce ampicillin, amoxycillin, Pivalic Acid cefazolin and other semi-synthetic antibiotics. Tylysine prepared with pivalic acid has good solubility, high curative effect and little side effect, and can be used for the treatment of rheumatoid arthritis. Benzylpentate can increase the stability of capillaries and can be used to treat tuberculosis. Fentanyl prepared by pivalic acid can be used as an active ingredient in the treatment of psoriasis ointment.

Initiator aspects of the application

Tert-butyl peroxide produced by the reaction of the acid chloride and tert-butyl peroxide to produce free radicals, the use of temperature can be as low as -50 ℃, with high efficiency, short induction period, short cycle and so on. In addition, it is used as a highly efficient initiator, the production of polymer thermal stability, good electrical properties, non-toxic, in the structure of the product with a large molecular weight and good linearity, etc., can be used as food packaging bags.

Nippon Oil and Fat Co., Ltd. with a special valence acid synthesis of a new peroxide initiator peroxide tert-hexyl pivaloyl (HPP), which is effective in the initiator, with non-toxic, low temperature activity and so on. The composite initiator system consisting of it and the efficient initiator, bis (2-ethylhexyl) dicarbonate, has many advantages in the production of PVC suspension: the polymerization time can be shortened, the reaction is exothermic and the process is easy to operate. Particle shape is good, "fish eyes" less, Pivalic Acid narrow molecular weight distribution range, product quality is good.

Especially valeric acid for the synthesis of the initiator there is a great potential, should increase the intensity of research.

Coating applications

The polyacrylic acid ester coating produced from the initiator made from pivalic acid is obtained by the selection of a specially constructed initiator and a chain transfer agent, Pivalic Acid as compared with those obtained by conventional initiators, the synthetic high solid content polyacrylate hinge Paint in the aging test showed a higher gloss and light retention performance.


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