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Pivaloyl Chloride Is A Very Important Acylation Reagent

Shandong Minji Chemical Co.,Ltd | Updated: Oct 09, 2017

Pivaloyl chloride is also known as pivaloyl chloride, tert-amanoyl chloride, Pivaloyl Chloride trimethyl acetyl chloride, 2,2-dimethyl propionyl chloride.

[Physical and chemical properties]:

Colorless or light yellow transparent liquid, flammable, flash point 19 ℃, boiling point 105-106 ℃, melting point -56 ℃, relative density

0.979-0.982 (20 ° C). With water, alkali, alcohol, oxidant contact reaction exothermic.

Pivaloyl chloride is a very important acylation reagent, Pivaloyl Chloride mainly used as pharmaceutical intermediates, in many amide and phenolic drugs in the preparation of the main raw materials; has been used for hydroxylamine penicillin and cefadroxil, cephalosporins Oxazoline, Pivaloyl Chloride bivalirvine adrenaline and other drugs. It is also used in large quantities for the production of pesticide intermediates such as chlorpentanoyl chloride and oxadiazone.

Pesticides and pharmaceutical intermediates for the production of ampicillin, cefazolin antibiotics, herbicides ketone (Nongsi it) insecticides, oxazole and pesticide wide-chi Ling, also used in the production of initiator TBPP, photographic materials And so on, Pivaloyl Chloride in the polymer polymerization has been widely used.


1 in medicine for the production of ampicillin ﹑ amoxicillin ﹑ cefazolin ﹑ ﹑ cefradizine ﹑ cefetazole ﹑ cefaclor, cefotristide ﹑ ceftazidime and so on.

2 in the use of pesticides for the production of dioxins and so on.

3 in the plastic industry for the production of initiator and so on.


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