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Special Valerate Is Used To Synthesize The Initiator

Shandong Minji Chemical Co.,Ltd | Updated: Oct 09, 2017

Pivalic acid (referred to as PA), CA registration number: 75-98-9, the formula: C5H10O2, the structural formula is: t-valeric acid, CH3H3CCCH3COHO has a molecular weight of 102.13, a white solid at room temperature, a special odor, a melting point of 35.5 ° C, a boiling point of 163 to 164 ° C, a density of 0.905 g / cm3 and a flash point of 63 ° C, Alcohol, ether, with a certain degree of corrosion. Pivalic Acid Should be placed in a dark place and filled with nitrogen or vacuum sealed storage, to prevent the product color becomes darker.

Vitamin is one of the most widely used alkyl carboxylic acids. As an important chemical raw materials and chemical reagents, mainly used in the synthesis of polymer initiators, pesticide intermediates, pharmaceutical intermediates, plasticizers, food additives, coatings, lubricants, glycidides, dispersants, spices, etc. Fine chemical products are also widely used in the synthesis. The main uses are as follows:

①, for the synthesis of initiator

Tert-butylperyl valerate catalyst, also known as initiator PV or BPP, from pivalic acid chloride and tert-butyl sodium peroxide prepared by the reaction. PV initiators are highly efficient initiators of high-pressure polyethylene, or are highly efficient initiators such as vinyl chloride, Pivalic Acid acrylate and vinyl acetate, which are more stable than other peroxide initiators and can be used in various Ph value aqueous solutions and low temperatures The

Nippon Oil and Fat Co., Ltd. uses trimethylacetic acid to synthesize new peroxide initiator, t-ethylpentyl peroxide, which is a medium-acting initiator with non-toxic, low temperature and high activity. It is used in the production of PVC suspension method, which can shorten the polymerization time and improve the production efficiency. Pivalic Acid The polymerization process is uniform and the heat dissipation is uniform. Molecular weight distribution range is narrow, improve product quality.

At present, there is a great potential for the research and development of pivalic acid for synthetic initiators, Pivalic Acid and its use and market demand are expanding.

②, for the synthesis of medicine

The acid chloride of pivalic acid (pivaloyl chloride, trimethyl acetyl chloride) is used to produce ampicillin, cefazolin antibiotics. Imak has reported that trimethylacetic acid has a pharmacological effect on the substituted phenyl ester, which has the effect of inhibiting the activity of pancreatic peptidase (elastase) for the treatment of emphysema, Pivalic Acid atherosclerosis and rheumatoid arthritis drug.

③, for the synthesis of pesticides

Pesticide 2 - [(2-chlorophenyl) methyl] -4,4-dimethyl-3-isoxazolone is a heterocyclic compound having a herbicidal effect and is an isoxazole The In its synthesis process with pivaloyl acid as the intermediate, first chlorinated pivaloyl chloride and hydroxylamine hydrochloride, Pivalic Acid sodium hydroxide in aqueous solution to produce 3-chloro-N-hydroxy-2,2-methylbenzamide. Then, 3-chloro-N-hydroxy-2,2-dimethylpropanamide is cyclized under the action of sodium hydroxide to form a 5-membered heterocyclic 4,4-dimethyl-3-isoxazole Alkanone. Finally, 4,4-dimethyl-3-isoxazolidinone is reacted with o-chlorobenzyl chloride to form 2 - [(2-chlorophenyl) methyl] -4,4-dimethyl- Oxazolone.

In addition to the use of synthetic ampicillin and other pharmaceuticals, pesticides, pivalic acid prepared "frequency ketone" can be used to produce pesticides "triadimefon, Pivalic Acid paclobutrazol" and other pesticides. New sunflower can be used for plant decay and cotton and soybeans, oats and other crops germination late herbicide.


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